Personalise vitamin D₃ using physiologically based pharmacokinetic modelling.

ABSTRACT: Plasma concentration of vitamin D₃ metabolite 25-hydroxyvitamin D₃ (25(OH)D₃ ) is variable among individuals. The objective of this study is to establish an accurate model for 25(OH)D₃ pharmacokinetics (PKs) to support selection of a suitable dose regimen for an individual. We collated vitamin D₃ and 25(OH)D₃ plasma PK data from reported clinical trials and developed a physiologically-based pharmacokinetic (PBPK) model to appropriately recapitulate training data. Model predictions were then qualified with 25(OH)D₃ plasma PKs under vitamin D₃ and 25(OH)D₃ dose regimens distinct from training data. From data exploration, we observed the increase in plasma 25(OH)D₃ after repeated dosi

SUBMITTER: Huang Z 

PROVIDER: S-EPMC8302240 | biostudies-literature | 2021 Jul

REPOSITORIES: biostudies-literature