A whole-body circulatory neutrophil model with application to predicting clinical neutropenia from in vitro studies.

ABSTRACT: A circulatory model of granulopoiesis and its regulation is presented that includes neutrophil trafficking in the lungs, liver, spleen, bone marrow, lymph nodes, and blood. In each organ, neutrophils undergo transendothelial migration from vascular to interstitial space, clearance due to apoptosis, and recycling via the lymphatic flow. The model includes cell cycling of progenitor cells in the bone marrow, granulocyte colony-stimulating factor (G-CSF) kinetics and its neutrophil regulatory action, as well as neutrophil margination in the blood. From previously reported studies, ¹¹¹ In-labeled neutrophil kinetic data in the blood and sampled organs were used to estimate the organ trafficking parameters in the model. The model was further developed and evaluated using absolute neu

SUBMITTER: Chen W 

PROVIDER: S-EPMC8302245 | biostudies-literature | 2021 Jul

REPOSITORIES: biostudies-literature