The role of IL-1 in adipose browning and muscle wasting in CKD-associated cachexia.

ABSTRACT: Cytokines such as IL-6, TNF-α and IL-1β trigger inflammatory cascades which may play a role in the pathogenesis of chronic kidney disease (CKD)-associated cachexia. CKD was induced by 5/6 nephrectomy in mice. We studied energy homeostasis in Il1β^-/-/CKD, Il6^-/-/CKD and Tnfα^-/-/CKD mice and compared with wild type (WT)/CKD controls. Parameters of cachexia phenotype were completely normalized in Il1β^-/-/CKD mice but were only partially rescued in Il6^-/-/CKD and Tnfα^-/-/CKD mice. We tested the effects of anakinra, an IL-1 receptor antagonist, on CKD-associated cachexia. WT/CKD mice were treated with anakinra (2.5 mg/kg/day, IP) or saline for 6 weeks and compared with WT/Sham controls. Anakinra normalized food intake and weight

SUBMITTER: Cheung WW 

PROVIDER: S-EPMC8302616 | biostudies-literature | 2021 Jul

REPOSITORIES: biostudies-literature