Intensive treat-to-target statin therapy and severity of diabetic retinopathy complicated by hypercholesterolaemia.

ABSTRACT:

Objectives

To compare the effects of intensive and standard statin therapy on severity of diabetic retinopathy (DR) complicated by hypercholesterolaemia in a prespecified substudy of the standard vs. intEnsive statin therapy for hypercholesteroleMic Patients with diAbetic retinopaTHY (EMPATHY) study.

Methods

Among 5144 patients in the multicentre, prospective, randomized EMPATHY study, this substudy considered 157 patients with seven-field fundus photographs of sufficient quality taken during study enrolment and at the 3-year visit. Eighty-five and seventy-two patients received intensive and standard statin treatments, respectively, in a treat-to-target manner. The primary endpoint was a two-step change in the Early Treatment Diabetic Retinopathy Study (ETDRS) DR severity sc

SUBMITTER: Murakami T 

PROVIDER: S-EPMC8302652 | biostudies-literature | 2021 Aug

REPOSITORIES: biostudies-literature