Ontology highlight
ABSTRACT:
SUBMITTER: Liu G
PROVIDER: S-EPMC8302679 | biostudies-literature | 2021 Jul
REPOSITORIES: biostudies-literature
Liu Guanzheng G Yu Jiefeng J Wu Runqiu R Shi Lin L Zhang Xu X Zhang Wanhong W Zhong Xiaomin X Wang Yifeng Y Li Huan H Shen Yang Y Wu Changyong C Yu Rutong R Niu Mingshan M Liu Xuejiao X
Cell death & disease 20210723 8
Glioblastoma multiforme (GBM) is an extremely aggressive brain tumor for which new therapeutic approaches are urgently required. Unfolded protein response (UPR) plays an important role in the progression of GBM and is a promising target for developing novel therapeutic interventions. We identified ubiquitin-activating enzyme 1 (UBA1) inhibitor TAK-243 that can strongly induce UPR in GBM cells. In this study, we evaluated the functional activity and mechanism of TAK-243 in preclinical models of G ...[more]