Inhibitory effects of Humulus japonicus extract against hepatic injury in a diabetic rat model.

ABSTRACT: Chronic diabetes mellitus (DM) can cause liver dysfunction and other complications. As Humulus japonicus is known to have anti-inflammatory and antioxidative effects, we sought to evaluate the hepatoprotective effect of H. japonicus extract (HJE) on a DM model. HJE reduced aspartate aminotransferase, alanine aminotransferase, and direct bilirubin levels and restored albumin activities relative to those found in the DM model. The abnormal levels of triglyceride, total cholesterol, high-density lipoprotein, and low-density lipoprotein in DM returned to normal levels after HJE treatment. DM-induced inflammation of the liver was ameliorated by HJE through reduction of tumor necrosis factor-α, interleukin-1β, and cyclooxygenase-2 levels. HJE treatment downregulated malondialdehyde

SUBMITTER: Kim TW 

PROVIDER: S-EPMC8302710 | biostudies-literature | 2021 Jul

REPOSITORIES: biostudies-literature