An Update on Hepatocellular Carcinoma in Chronic Kidney Disease.

ABSTRACT: Chronic kidney disease is a major public health issue globally and the risk of cancer (including HCC) is greater in patients on long-term dialysis and kidney transplant compared with the general population. According to an international study on 831,804 patients on long-term dialysis, the standardized incidence ratio for liver cancer was 1.2 (95% CI, 1.0-1.4) and 1.5 (95% CI, 1.3-1.7) in European and USA cohorts, respectively. It appears that important predictors of HCC in dialysis population are hepatotropic viruses (HBV and HCV) and cirrhosis. 1-, 3-, and 5-year survival rates are lower in HCC patients on long-term dialysis than those with HCC and intact kidneys. NAFLD is a metabolic disease with increasing prevalence worldwide and recent evidence shows that it is an important cause of l

SUBMITTER: Fabrizi F 

PROVIDER: S-EPMC8303325 | biostudies-literature | 2021 Jul

REPOSITORIES: biostudies-literature