Complement Factor C5a Inhibits Apoptosis of Neutrophils-A Mechanism in Polytrauma?

ABSTRACT: Life-threatening polytrauma results in early activation of the complement and apoptotic system, as well as leukocytes, ultimately leading to the clearance of damaged cells. However, little is known about interactions between the complement and apoptotic systems in PMN (polymorphonuclear neutrophils) after multiple injuries. PMN from polytrauma patients and healthy volunteers were obtained and assessed for apoptotic events along the post-traumatic time course. In vitro studies simulated complement activation by the exposure of PMN to C3a or C5a and addressed both the intrinsic and extrinsic apoptotic pathway. Specific blockade of the C5a-receptor 1 (C5aR1) on PMN was evaluated for efficacy to reverse complement-driven alterations. PMN from polytrauma patients exhibited significantly reduced

SUBMITTER: Ehrnthaller C 

PROVIDER: S-EPMC8303460 | biostudies-literature | 2021 Jul

REPOSITORIES: biostudies-literature