Establishment and Validation of CyberKnife Irradiation in a Syngeneic Glioblastoma Mouse Model.

ABSTRACT: CyberKnife stereotactic radiosurgery (CK-SRS) precisely delivers radiation to intracranial tumors. However, the underlying radiobiological mechanisms at high single doses are not yet fully understood. Here, we established and evaluated the early radiobiological effects of CK-SRS treatment at a single dose of 20 Gy after 15 days of tumor growth in a syngeneic glioblastoma-mouse model. Exact positioning was ensured using a custom-made, non-invasive, and trackable frame. One superimposed target volume for the CK-SRS planning was created from the fused tumor volumes obtained from MRIs prior to irradiation. Dose calculation and delivery were planned using a single-reference CT scan. Six days after irradiation, tumor volumes were measured using MRI scans, and radiobiological effects were assesse

SUBMITTER: Jelgersma C 

PROVIDER: S-EPMC8303959 | biostudies-literature | 2021 Jul

REPOSITORIES: biostudies-literature