¹⁸F-FMISO-PET Hypoxia Monitoring for Head-and-Neck Cancer Patients: Radiomics Analyses Predict the Outcome of Chemo-Radiotherapy.

ABSTRACT: Tumor hypoxia is associated with radiation resistance and can be longitudinally monitored by ¹⁸F-fluoromisonidazole (¹⁸F-FMISO)-PET/CT. Our study aimed at evaluating radiomics dynamics of ¹⁸F-FMISO-hypoxia imaging during chemo-radiotherapy (CRT) as predictors for treatment outcome in head-and-neck squamous cell carcinoma (HNSCC) patients. We prospectively recruited 35 HNSCC patients undergoing definitive CRT and longitudinal ¹⁸F-FMISO-PET/CT scans at weeks 0, 2 and 5 (W0/W2/W5). Patients were classified based on peritherapeutic variations of the hypoxic sub-volume (HSV) size (increasing/stable/decreasing) and location (geographically-static/geographically-dynamic) by a new objective classification parameter (CP) accounting for spatial overlap. Ad

SUBMITTER: Carles M 

PROVIDER: S-EPMC8303992 | biostudies-literature | 2021 Jul

REPOSITORIES: biostudies-literature