Nuclear Organization during Hepatogenesis in Zebrafish Requires Uhrf1.

ABSTRACT: Acquisition of cellular fate during development is initiated and maintained by well-coordinated patterns of gene expression that are dictated by the epigenetic landscape and genome organization in the nucleus. While the epigenetic marks that mediate developmental gene expression patterns during organogenesis have been well studied, less is known about how epigenetic marks influence nuclear organization during development. This study examines the relationship between nuclear structure, chromatin accessibility, DNA methylation, and gene expression during hepatic outgrowth in zebrafish larvae. We investigate the relationship between these features using mutants that lack DNA methylation. Hepatocyte nuclear morphology was established coincident with hepatocyte differentiation at 80 h post-fert

SUBMITTER: Madakashira BP 

PROVIDER: S-EPMC8304062 | biostudies-literature | 2021 Jul

REPOSITORIES: biostudies-literature