Integrin-Linked Kinase (ILK) Plays an Important Role in the Laminin-Dependent Development of Dorsal Root Ganglia during Chicken Embryogenesis.

ABSTRACT: Integrin-linked kinase (ILK) is mainly localized in focal adhesions where it interacts and modulates the downstream signaling of integrins affecting cell migration, adhesion, and survival. The interaction of dorsal root ganglia (DRG) cells, being part of the peripheral nervous system (PNS), with the extracellular matrix (ECM) via integrins is crucial for proper PNS development. A few studies have focused on ILK's role in PNS development, but none of these have focused on chicken. Therefore, we decided to investigate ILK's role in the development of Gallus gallus domesticus's DRG. First, using RT-PCR, Western blotting, and in situ hybridization, we show that ILK is expressed in DRG. Next, by immunocytochemistry, we show ILK's localization both intracellularly and on the cell m

SUBMITTER: Mrowczynska E 

PROVIDER: S-EPMC8304069 | biostudies-literature | 2021 Jul

REPOSITORIES: biostudies-literature