Diagnosis of Ion-Exchange Resin Depositions in Paraffin Sections Using Correlative Light and Electron Microscopy-NanoSuit Method.

ABSTRACT: Ion-exchange resins are commonly used to treat complications such as hyperkalemia, hyperphosphatemia, and hypercholesterolemia. Gastrointestinal complications may occur as side effects of such treatments. Sodium and calcium polystyrene sulfonate (PS-Ca) are cation-exchange resins comprising an insoluble structure that binds to potassium ions in the digestive tract and exchanges them with sodium and calcium ions, respectively, to promote their elimination. PS crystals are rhomboid, refractive, and basophilic in hematoxylin and eosin staining. To differentiate PS crystals from other ion-exchange resin crystals such as sevelamer and cholestyramine, periodic acid-Schiff, Ziehl-Neelsen, and Congo red staining are usually performed. Here, correlative light and electron microscopy (CLEM)-energy-d

SUBMITTER: Ooishi M 

PROVIDER: S-EPMC8304092 | biostudies-literature | 2021 Jun

REPOSITORIES: biostudies-literature