Retinoids as Chemo-Preventive and Molecular-Targeted Anti-Cancer Therapies.

ABSTRACT: Retinoic acid (RA) agents possess anti-tumor activity through their ability to induce cellular differentiation. However, retinoids have not yet been translated into effective systemic treatments for most solid tumors. RA signaling is mediated by the following two nuclear retinoic receptor subtypes: the retinoic acid receptor (RAR) and the retinoic X receptor (RXR), and their isoforms. The identification of mutations in retinoid receptors and other RA signaling pathway genes in human cancers offers opportunities for target discovery, drug design, and personalized medicine for distinct molecular retinoid subtypes. For example, chromosomal translocation involving RARA occurs in acute promyelocytic leukemia (APL), and all-trans retinoic acid (ATRA) is a highly effective and even curative thera

SUBMITTER: Hunsu VO 

PROVIDER: S-EPMC8304138 | biostudies-literature | 2021 Jul

REPOSITORIES: biostudies-literature