Early Vitamin C, Hydrocortisone, and Thiamine Treatment for Septic Cardiomyopathy: A Propensity Score Analysis.

ABSTRACT: This study investigated the effectiveness of early vitamin C, hydrocortisone, and thiamine among patients with septic cardiomyopathy. In total, 91 patients with septic cardiomyopathy received a vitamin C protocol in September 2018-February 2020. These patients were compared to 75 patients with septic cardiomyopathy who did not receive a vitamin C protocol in September 2016-February 2018. Relative to the control patients, the treated patients were older and more likely to require mechanical ventilation. The vitamin C protocol was associated with a lower risk of intensive care unit mortality in the propensity score (PS)-matched cohort (aHR: 0.55, 95% CI: 0.30-0.99) and inverse probability of treatment weighting-matched cohort (aHR: 0.67, 95% CI: 0.45-1.00). In the PS-matched cohort (59 patie

SUBMITTER: Lee MT 

PROVIDER: S-EPMC8304272 | biostudies-literature | 2021 Jun

REPOSITORIES: biostudies-literature