Cisplatin Resistance and Redox-Metabolic Vulnerability: A Second Alteration.

ABSTRACT: The development of drug resistance in tumors is a major obstacle to effective cancer chemotherapy and represents one of the most significant complications to improving long-term patient outcomes. Despite early positive responsiveness to platinum-based chemotherapy, the majority of lung cancer patients develop resistance. The development of a new combination therapy targeting cisplatin-resistant (CR) tumors may mark a major improvement as salvage therapy in these patients. The recent resurgence in research into cellular metabolism has again confirmed that cancer cells utilize aerobic glycolysis ("the Warburg effect") to produce energy. Hence, this observation still remains a characteristic hallmark of altered metabolism in certain cancer cells. However, recent evidence promotes another conc

SUBMITTER: Wangpaichitr M 

PROVIDER: S-EPMC8304747 | biostudies-literature | 2021 Jul

REPOSITORIES: biostudies-literature