Children's Greenness Exposure and IQ-Associated DNA Methylation: A Prospective Cohort Study.

ABSTRACT: Epigenetics is known to be involved in regulatory pathways through which greenness exposure influences child development and health. We aimed to investigate the associations between residential surrounding greenness and DNA methylation changes in children, and further assessed the association between DNA methylation and children's intelligence quotient (IQ) in a prospective cohort study. We identified cytosine-guanine dinucleotide sites (CpGs) associated with cognitive abilities from epigenome- and genome-wide association studies through a systematic literature review for candidate gene analysis. We estimated the residential surrounding greenness at age 2 using a geographic information system. DNA methylation was analyzed from whole blood using the HumanMethylationEPIC array in 59 children

SUBMITTER: Lee KS 

PROVIDER: S-EPMC8304819 | biostudies-literature | 2021 Jul

REPOSITORIES: biostudies-literature