The Multifactorial Progression from the Islet Autoimmunity to Type 1 Diabetes in Children.

ABSTRACT: Type 1 Diabetes (T1D) results from autoimmune destruction of insulin producing pancreatic ß-cells. This disease, with a peak incidence in childhood, causes the lifelong need for insulin injections and necessitates careful monitoring of blood glucose levels. However, despite the current insulin therapies, it still shortens life expectancy due to complications affecting multiple organs. Recently, the incidence of T1D in childhood has increased by 3-5% per year in most developed Western countries. The heterogeneity of the disease process is supported by the findings of follow-up studies started early in infancy. The development of T1D is usually preceded by the appearance of autoantibodies targeted against antigens expressed in the pancreatic islets. The risk of T1D increases significantly wi

SUBMITTER: Bauer W 

PROVIDER: S-EPMC8305179 | biostudies-literature | 2021 Jul

REPOSITORIES: biostudies-literature