DIAPH2, PTPRD and HIC1 Gene Polymorphisms and Laryngeal Cancer Risk.

ABSTRACT: AIM, DIAPH2, PTPRD and HIC1 are the cell glycoprotein, which play an important role in the occurrence and development of tumors. This study was designed to assess the association between DIAPH2, PTPRD and HIC1 SNPs and laryngeal cancer risk.

Patients and methods

This study including 267 patients with histologically confirmed laryngeal cancer and 157 controls. The relationship between genetic variations DIAPH2 (rs6620138), PTPRD (rs3765142) and HIC1 (rs9901806) and the onset of laryngeal cancer were investigated. Statistical analysis to calculate the relationship between DIAPH2, PTPRD and HIC1 genes polymorphism and pathogenesis of laryngeal cancer.

Results

The results showed that rs6620138 DIAPH2 polymorphism could increase the onset risk of laryngeal cancer. Statistically si

SUBMITTER: Snit M 

PROVIDER: S-EPMC8305316 | biostudies-literature | 2021 Jul

REPOSITORIES: biostudies-literature