Individualized Prognostic Prediction of the Long-Term Functional Trajectory in Pediatric Acquired Brain Injury.

ABSTRACT: In pediatric acquired brain injury, heterogeneity of functional response to specific rehabilitation treatments is a key confound to medical decisions and outcome prediction. We aimed to identify patient subgroups sharing comparable trajectories, and to implement a method for the early prediction of the long-term recovery course from clinical condition at first discharge. 600 consecutive patients with acquired brain injury (7.4 years ± 5.2; 367 males; median GCS = 6) entered a standardized rehabilitation program. Functional Independent Measure scores were measured yearly, until year 7. We classified the functional trajectories in clusters, through a latent class model. We performed single-subject prediction of trajectory membership in cases unseen during model fitting. Four trajectory types

SUBMITTER: Molteni E 

PROVIDER: S-EPMC8305391 | biostudies-literature | 2021 Jul

REPOSITORIES: biostudies-literature