Non-Invasive Differentiation of M1 and M2 Activation in Macrophages Using Hyperpolarized ¹³C MRS of Pyruvate and DHA at 1.47 Tesla.

ABSTRACT: Macrophage activation, first generalized to the M1/M2 dichotomy, is a complex and central process of the innate immune response. Simply, M1 describes the classical proinflammatory activation, leading to tissue damage, and M2 the alternative activation promoting tissue repair. Given the central role of macrophages in multiple diseases, the ability to noninvasively differentiate between M1 and M2 activation states would be highly valuable for monitoring disease progression and therapeutic responses. Since M1/M2 activation patterns are associated with differential metabolic reprogramming, we hypothesized that hyperpolarized ¹³C magnetic resonance spectroscopy (HP ¹³C MRS), an innovative metabolic imaging approach, could distinguish between macrophage activation states no

SUBMITTER: Qiao K 

PROVIDER: S-EPMC8305442 | biostudies-literature | 2021 Jun

REPOSITORIES: biostudies-literature