Improving the Utility of Polygenic Risk Scores as a Biomarker for Alzheimer's Disease.

ABSTRACT: The treatment of complex and multifactorial diseases constitutes a big challenge in day-to-day clinical practice. As many parameters influence clinical phenotypes, accurate diagnosis and prompt therapeutic management is often difficult. Significant research and investment focuses on state-of-the-art genomic and metagenomic analyses in the burgeoning field of Precision (or Personalized) Medicine with genome-wide-association-studies (GWAS) helping in this direction by linking patient genotypes at specific polymorphic sites (single-nucleotide polymorphisms, SNPs) to the specific phenotype. The generation of polygenic risk scores (PRSs) is a relatively novel statistical method that associates the collective genotypes at many of a person's SNPs to a trait or disease. As GWAS sample sizes

SUBMITTER: Vlachakis D 

PROVIDER: S-EPMC8305482 | biostudies-literature | 2021 Jun

REPOSITORIES: biostudies-literature