Statistical analysis of two arm randomized pre-post designs with one post-treatment measurement.

ABSTRACT:

Background

Randomized pre-post designs, with outcomes measured at baseline and after treatment, have been commonly used to compare the clinical effectiveness of two competing treatments. There are vast, but often conflicting, amount of information in current literature about the best analytic methods for pre-post designs. It is challenging for applied researchers to make an informed choice.

Methods

We discuss six methods commonly used in literature: one way analysis of variance ("ANOVA"), analysis of covariance main effect and interaction models on the post-treatment score ("ANCOVAI" and "ANCOVAII"), ANOVA on the change score between the baseline and post-treatment scores ("ANOVA-Change"), repeated measures ("RM") and constrained repeated measures ("cRM") models on the basel

SUBMITTER: Wan F 

PROVIDER: S-EPMC8305561 | biostudies-literature | 2021 Jul

REPOSITORIES: biostudies-literature