Successful Dissemination of Plasmid-Mediated Extended-Spectrum β-Lactamases in Enterobacterales over Humans to Wild Fauna.

ABSTRACT:

Background

The emergence of multidrug-resistant bacteria remains poorly understood in the wild ecosystem and at the interface of habitats. Here, we explored the spread of Escherichia coli containing IncI1-ST3 plasmid encoding resistance gene cefotaximase-Munich-1 (bla_CTX-M-1) in human-influenced habitats and wild fauna using a genomic approach.

Methods

Multilocus sequence typing (MLST), single-nucleotide polymorphism comparison, synteny-based analysis and data mining approaches were used to analyse a dataset of genomes and circularised plasmids.

Results

CTX-M-1 E. coli sequence types (STs) were preferentially associated with ecosystems. Few STs were shared by distinct habitats. IncI1-ST3-bla_CTX-M-1 plasmids are

SUBMITTER: Beyrouthy R 

PROVIDER: S-EPMC8305760 | biostudies-literature | 2021 Jul

REPOSITORIES: biostudies-literature