Systems Pharmacology-Based Precision Therapy and Drug Combination Discovery for Breast Cancer.

ABSTRACT: Breast cancer (BC) is a common disease and one of the main causes of death in females worldwide. In the omics era, researchers have used various high-throughput sequencing technologies to accumulate massive amounts of biomedical data and reveal an increasing number of disease-related mutations/genes. It is a major challenge to use these data effectively to find drugs that may protect human health. In this study, we combined the GeneRank algorithm and gene dependency network to propose a precision drug discovery strategy that can recommend drugs for individuals and screen existing drugs that could be used to treat different BC subtypes. We used this strategy to screen four BC subtype-specific drug combinations and verified the potential activity of combining gefitinib and irinotecan in trip

SUBMITTER: Cui ZJ 

PROVIDER: S-EPMC8305788 | biostudies-literature | 2021 Jul

REPOSITORIES: biostudies-literature