Sigma-1 Receptor Promotes Mitochondrial Bioenergetics by Orchestrating ER Ca²⁺ Leak during Early ER Stress.

ABSTRACT: The endoplasmic reticulum (ER) is a complex, multifunctional organelle of eukaryotic cells and responsible for the trafficking and processing of nearly 30% of all human proteins. Any disturbance to these processes can cause ER stress, which initiates an adaptive mechanism called unfolded protein response (UPR) to restore ER functions and homeostasis. Mitochondrial ATP production is necessary to meet the high energy demand of the UPR, while the molecular mechanisms of ER to mitochondria crosstalk under such stress conditions remain mainly enigmatic. Thus, better understanding the regulation of mitochondrial bioenergetics during ER stress is essential to combat many pathologies involving ER stress, the UPR, and mitochondria. This article investigates the role of Sigma-1 Receptor (S1R), an ER

SUBMITTER: Koshenov Z 

PROVIDER: S-EPMC8305890 | biostudies-literature | 2021 Jun

REPOSITORIES: biostudies-literature