Urinary Extracellular Vesicles and Their miRNA Cargo in Patients with Fabry Nephropathy.

ABSTRACT: Current biomarkers of Fabry nephropathy lack sensitivity in detecting early kidney damage and do not predict progression of nephropathy. Urinary extracellular vesicles (uEVs) and their molecular cargo could reflect early changes in renal impairment as they are secreted by the cells lining the urinary tract. We aimed to conduct a proof-of-concept study to investigate whether analysis of uEV characteristics and expression of uEV-derived microRNAs (miRNAs) could be applicable in studies to predict the development and progression of nephropathy in Fabry disease. A total of 20 Fabry patients were divided into two groups, depending on the presence of nephropathy. Chronological urine samples collected during 10-year follow-up were used for uEVs isolation with size exclusion chromatography. Nanopa

SUBMITTER: Levstek T 

PROVIDER: S-EPMC8305897 | biostudies-literature | 2021 Jul

REPOSITORIES: biostudies-literature