Plaque-associated human microglia accumulate lipid droplets in a chimeric model of Alzheimer's disease.

ABSTRACT:

Background

Disease-associated microglia (DAMs), that surround beta-amyloid plaques, represent a transcriptionally-distinct microglial profile in Alzheimer's disease (AD). Activation of DAMs is dependent on triggering receptor expressed on myeloid cells 2 (TREM2) in mouse models and the AD TREM2-R47H risk variant reduces microglial activation and plaque association in human carriers. Interestingly, TREM2 has also been identified as a microglial lipid-sensor, and recent data indicates lipid droplet accumulation in aged microglia, that is in turn associated with a dysfunctional proinflammatory phenotype. However, whether lipid droplets (LDs) are present in human microglia in AD and how the R47H mutation affects this remains unknown.

Methods

To determine the impact of the TREM2

SUBMITTER: Claes C 

PROVIDER: S-EPMC8305935 | biostudies-literature | 2021 Jul

REPOSITORIES: biostudies-literature