COMTOP: Protein Residue-Residue Contact Prediction through Mixed Integer Linear Optimization.

ABSTRACT: Protein contact prediction helps reconstruct the tertiary structure that greatly determines a protein's function; therefore, contact prediction from the sequence is an important problem. Recently there has been exciting progress on this problem, but many of the existing methods are still low quality of prediction accuracy. In this paper, we present a new mixed integer linear programming (MILP)-based consensus method: a Consensus scheme based On a Mixed integer linear opTimization method for prOtein contact Prediction (COMTOP). The MILP-based consensus method combines the strengths of seven selected protein contact prediction methods, including CCMpred, EVfold, DeepCov, NNcon, PconsC4, plmDCA, and PSICOV, by optimizing the number of correctly predicted contacts and achieving a better predic

SUBMITTER: Reza MS 

PROVIDER: S-EPMC8305966 | biostudies-literature | 2021 Jun

REPOSITORIES: biostudies-literature