Symptoms of Prenatal Depression Associated with Shorter Telomeres in Female Placenta.

ABSTRACT: Depression is a common mood disorder during pregnancy impacting one in every seven women. Children exposed to prenatal depression are more likely to be born at a low birth weight and develop chronic diseases later in life. A proposed hypothesis for this relationship between early exposure to adversity and poor outcomes is accelerated aging. Telomere length has been used as a biomarker of cellular aging. We used high-resolution telomere length analysis to examine the relationship between placental telomere length distributions and maternal mood symptoms in pregnancy. This study utilised samples from the longitudinal Grown in Wales (GiW) study. Women participating in this study were recruited at their presurgical appointment prior to a term elective caesarean section (ELCS). Women completed

SUBMITTER: Garcia-Martin I 

PROVIDER: S-EPMC8306199 | biostudies-literature | 2021 Jul

REPOSITORIES: biostudies-literature