Insights into the molecular mechanisms of Huangqi decoction on liver fibrosis via computational systems pharmacology approaches.

ABSTRACT:

Background

The traditional Chinese medicine Huangqi decoction (HQD) consists of Radix Astragali and Radix Glycyrrhizae in a ratio of 6: 1, which has been used for the treatment of liver fibrosis. In this study, we tried to elucidate its action of mechanism (MoA) via a combination of metabolomics data, network pharmacology and molecular docking methods.

Methods

Firstly, we collected prototype components and metabolic products after administration of HQD from a publication. With known and predicted targets, compound-target interactions were obtained. Then, the global compound-liver fibrosis target bipartite network and the HQD-liver fibrosis protein-protein interaction network were constructed, separately. KEGG pathway analysis was applied to further understand the mechanisms

SUBMITTER: Wang B 

PROVIDER: S-EPMC8306236 | biostudies-literature | 2021 Jul

REPOSITORIES: biostudies-literature