Reduced Expression of Slc Genes in the VTA and NAcc of Male Mice with Positive Fighting Experience.

ABSTRACT: A range of several psychiatric medications targeting the activity of solute carrier (SLC) transporters have proved effective for treatment. Therefore, further research is needed to elucidate the expression profiles of the Slc genes, which may serve as markers of altered brain metabolic processes and neurotransmitter activities in psychoneurological disorders. We studied the Slc differentially expressed genes (DEGs) using transcriptomic profiles in the ventral tegmental area (VTA), nucleus accumbens (NAcc), and prefrontal cortex (PFC) of control and aggressive male mice with psychosis-like behavior induced by repeated experience of aggression accompanied with wins in daily agonistic interactions. The majority of the Slc DEGs were shown to have brain region-specific expression profiles. Most

SUBMITTER: Smagin DA 

PROVIDER: S-EPMC8306410 | biostudies-literature | 2021 Jul

REPOSITORIES: biostudies-literature