The Effects of Oxytocin on Appetite Regulation, Food Intake and Metabolism in Humans.

ABSTRACT: The hypothalamic peptide oxytocin and its receptor are involved in a range of physiological processes, including parturition, lactation, cell growth, wound healing, and social behavior. More recently, increasing evidence has established the effects of oxytocin on food intake, energy expenditure, and peripheral metabolism. In this review, we provide a comprehensive description of the central oxytocinergic system in which oxytocin acts to shape eating behavior and metabolism. Next, we discuss the peripheral beneficial effects oxytocin exerts on key metabolic organs, including suppression of visceral adipose tissue inflammation, skeletal muscle regeneration, and bone tissue mineralization. A brief summary of oxytocin actions learned from animal models is presented, showing that weight loss in

SUBMITTER: Kerem L 

PROVIDER: S-EPMC8306733 | biostudies-literature | 2021 Jul

REPOSITORIES: biostudies-literature