Keratinocytes Regulate the Threshold of Inflammation by Inhibiting T Cell Effector Functions.

ABSTRACT: Whilst the importance of keratinocytes as a first-line defense has been widely investigated, little is known about their interactions with non-resident immune cells. In this study, the impact of human keratinocytes on T cell effector functions was analyzed in an antigen-specific in vitro model of allergic contact dermatitis (ACD) to nickel sulfate. Keratinocytes partially inhibited T cell proliferation and cytokine production. This effect was dependent on the keratinocyte/T cell ratio and was partially reversible by increasing the number of autologous dendritic cells. The inhibition of T cell proliferation by keratinocytes was independent of the T cell subtype and antigen presentation by different professional antigen-presenting cells. Autologous and heterologous keratinocytes showed compa

SUBMITTER: Seiringer P 

PROVIDER: S-EPMC8306889 | biostudies-literature | 2021 Jun

REPOSITORIES: biostudies-literature