Ontology highlight
ABSTRACT:
SUBMITTER: Lin YH
PROVIDER: S-EPMC8306951 | biostudies-literature | 2021 Jun
REPOSITORIES: biostudies-literature
Lin Yu-Hsuan YH Lin Yueh-Chien YC Chen Chien-Chin CC
Cells 20210629 7
Lysophosphatidic acid (LPA) is a bioactive lipid mediator primarily derived from membrane phospholipids. LPA initiates cellular effects upon binding to a family of G protein-coupled receptors, termed LPA receptors (LPAR1 to LPAR6). LPA signaling drives cell migration and proliferation, cytokine production, thrombosis, fibrosis, angiogenesis, and lymphangiogenesis. Since the expression and function of LPA receptors are critical for cellular effects, selective antagonists may represent a potential ...[more]