Functional Redundancy and Specialization of the Conserved Cold Shock Proteins in Bacillus subtilis.

ABSTRACT: Many bacteria encode so-called cold shock proteins. These proteins are characterized by a conserved protein domain. Often, the bacteria have multiple cold shock proteins that are expressed either constitutively or at low temperatures. In the Gram-positive model bacterium Bacillussubtilis, two of three cold shock proteins, CspB and CspD, belong to the most abundant proteins suggesting a very important function. To get insights into the role of these highly abundant proteins, we analyzed the phenotypes of single and double mutants, tested the expression of the csp genes and the impact of CspB and CspD on global gene expression in B. subtilis. We demonstrate that the simultaneous loss of both CspB and CspD results in a severe growth defect, in the loss of genetic c

SUBMITTER: Faßhauer P 

PROVIDER: S-EPMC8307031 | biostudies-literature | 2021 Jul

REPOSITORIES: biostudies-literature