MicroRNAs in Prion Diseases-From Molecular Mechanisms to Insights in Translational Medicine.

ABSTRACT: MicroRNAs (miRNAs) are small non-coding RNA molecules able to post-transcriptionally regulate gene expression via base-pairing with partially complementary sequences of target transcripts. Prion diseases comprise a singular group of neurodegenerative conditions caused by endogenous, misfolded pathogenic (prion) proteins, associated with molecular aggregates. In humans, classical prion diseases include Creutzfeldt-Jakob disease, fatal familial insomnia, Gerstmann-Sträussler-Scheinker syndrome, and kuru. The aim of this review is to present the connections between miRNAs and prions, exploring how the interaction of both molecular actors may help understand the susceptibility, onset, progression, and pathological findings typical of such disorders, as well as the interface with some prion-lik

SUBMITTER: Contiliani DF 

PROVIDER: S-EPMC8307047 | biostudies-literature | 2021 Jun

REPOSITORIES: biostudies-literature