The Genomic Landscape of a Restricted ALL Cohort from Patients Residing on the U.S./Mexico Border.

ABSTRACT: Next-generation sequencing (NGS) has identified unique biomarkers yielding new strategies in precision medicine for the treatment of Acute lymphoblastic leukemia (ALL). Hispanics show marked health disparities in ALL, often absent in clinical trials or cancer research. Thus, it is unknown whether Hispanics would benefit equally from curated data currently guiding precision oncology. Using whole-exome sequencing, nine ALL patients were screened for mutations within genes known to possess diagnostic, prognostic and therapeutic value. Genes mutated in Hispanic ALL patients from the borderland were mined for potentially pathogenic variants within clinically relevant genes. KRAS G12A was detected in this unique cohort and its frequency in Hispanics from the TARGET-ALL Phase II database was thre

SUBMITTER: Grant AH 

PROVIDER: S-EPMC8307122 | biostudies-literature | 2021 Jul

REPOSITORIES: biostudies-literature