Ontology highlight
ABSTRACT:
SUBMITTER: Mladenova K
PROVIDER: S-EPMC8307467 | biostudies-literature | 2021 Jul
REPOSITORIES: biostudies-literature
Mladenova Kirilka K Stavrakov Georgi G Philipova Irena I Atanasova Mariyana M Petrova Svetla S Doumanov Jordan J Doytchinova Irini I
International journal of molecular sciences 20210715 14
Misfolded amyloid beta (Aβ) peptides aggregate and form neurotoxic oligomers. Membrane and mitochondrial damages, calcium dysregulation, oxidative stress, and fibril deposits are among the possible mechanisms of Aβ cytotoxicity. Galantamine (GAL) prevents apoptosis induced by Aβ mainly through the ability to stimulate allosterically the α7 nAChRs and to regulate the calcium cytosolic concentration. Here, we examined the cytoprotective effects of two GAL derivatives, namely compounds <b>4b</b> an ...[more]