Ontology highlight
ABSTRACT:
SUBMITTER: Terrie E
PROVIDER: S-EPMC8307764 | biostudies-literature | 2021 Jul
REPOSITORIES: biostudies-literature
Terrié Elodie E Déliot Nadine N Benzidane Yassine Y Harnois Thomas T Cousin Laëtitia L Bois Patrick P Oliver Lisa L Arnault Patricia P Vallette François F Constantin Bruno B Coronas Valérie V
Cancers 20210708 14
Glioblastoma is the most frequent and deadly form of primary brain tumors. Despite multimodal treatment, more than 90% of patients experience tumor recurrence. Glioblastoma contains a small population of cells, called glioblastoma stem cells (GSC) that are highly resistant to treatment and endowed with the ability to regenerate the tumor, which accounts for tumor recurrence. Transcriptomic studies disclosed an enrichment of calcium (Ca<sup>2+</sup>) signaling transcripts in GSC. In non-excitable ...[more]