Dataset Information

Effect of Cold Rolling on the Evolution of Shear Bands and Nanoindentation Hardness in Zr41.2Ti13.8Cu12.5Ni10Be22.5 Bulk Metallic Glass.

ABSTRACT: The effect of cold rolling on the evolution of hardness (H) and Young's modulus (E) on the rolling-width (RW), normal-rolling (NR), and normal-width (NW) planes in Zr41.2Ti13.8Cu12.5Ni10Be22.5 (Vitreloy 1) bulk metallic glass (BMG) was investigated systematically using nanoindentation at peak loads in the range of 50 mN-500 mN. The hardness at specimen surface varied with cold rolling percentage (%) and the variation is similar on RW and NR planes at all the different peak loads, whereas the same is insignificant for the core region of the specimen on the NW plane. Three-dimensional (3D) optical surface profilometry studies on the NR plane suggest that the shear band spacing decreases and shear band offset height increases with the increase of cold rolling extent. Meanwhile, the number of the pop-in events during loading for all the planes reduces with the increase of cold rolling extent pointing to more homogeneous deformation upon rolling. Calorimetric studies were performed to correlate the net free volume content and hardness in the differently cold rolled specimens.

SUBMITTER: Gunti A

PROVIDER: S-EPMC8307797 | biostudies-literature | 2021 Jun

REPOSITORIES: biostudies-literature

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Publications

Effect of Cold Rolling on the Evolution of Shear Bands and Nanoindentation Hardness in Zr41.2Ti13.8Cu12.5Ni10Be22.5 Bulk Metallic Glass.

Gunti Abhilash A Jana Parijat Pallab PP Lee Min-Ha MH Das Jayanta J

Nanomaterials (Basel, Switzerland) 20210625 7

The effect of cold rolling on the evolution of hardness (H) and Young's modulus (E) on the rolling-width (RW), normal-rolling (NR), and normal-width (NW) planes in Zr41.2Ti13.8Cu12.5Ni10Be22.5 (Vitreloy 1) bulk metallic glass (BMG) was investigated systematically using nanoindentation at peak loads in the range of 50 mN-500 mN. The hardness at specimen surface varied with cold rolling percentage (%) and the variation is similar ...[more]

PMID: 34201987

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Project description:Polarization of macrophages by chemical, topographical and mechanical cues presents a robust strategy for designing immunomodulatory biomaterials. Here, we studied the ability of nanopatterned bulk metallic glasses (BMGs), a new class of metallic biomaterials, to modulate murine macrophage polarization. Cytokine/chemokine analysis of IL-4 or IFNγ/LPS-stimulated macrophages showed that the secretion of TNF-α, IL-1α, IL-12, CCL-2 and CXCL1 was significantly reduced after 24-hour culture on BMGs with 55 nm nanorod arrays (BMG-55). Additionally, under these conditions, macrophages increased phagocytic potential and exhibited decreased cell area with multiple actin protrusions. These in vitro findings suggest that nanopatterning can modulate biochemical cues such as IFNγ/LPS. In vivo evaluation of the subcutaneous host response at 2 weeks demonstrated that the ratio of Arg-1 to iNOS increased in macrophages adjacent to BMG-55 implants, suggesting modulation of polarization. In addition, macrophage fusion and fibrous capsule thickness decreased and the number and size of blood vessels increased, which is consistent with changes in macrophage responses. Our study demonstrates that nanopatterning of BMG implants is a promising technique to selectively polarize macrophages to modulate the immune response, and also presents an effective tool to study mechanisms of macrophage polarization and function.Statement of significanceImplanted biomaterials elicit a complex series of tissue and cellular responses, termed the foreign body response (FBR), that can be influenced by the polarization state of macrophages. Surface topography can influence polarization, which is broadly characterized as either inflammatory or repair-like. The latter has been linked to improved outcomes of the FBR. However, the impact of topography on macrophage polarization is not fully understood, in part, due to a lack of high moduli biomaterials that can be reproducibly processed at the nanoscale. Here, we studied macrophage interactions with nanopatterned bulk metallic glasses (BMGs), a class of metallic alloys with amorphous microstructure and formability like polymers. We show that nanopatterned BMGs modulate macrophage polarization and transiently induce less fibrotic and more angiogenic responses. Overall, we demonstrate nanopatterning of BMG implants as a technique to polarize macrophages and modulate the FBR.

Dataset Information

Effect of Cold Rolling on the Evolution of Shear Bands and Nanoindentation Hardness in Zr41.2Ti13.8Cu12.5Ni10Be22.5 Bulk Metallic Glass.

Publications

Effect of Cold Rolling on the Evolution of Shear Bands and Nanoindentation Hardness in Zr<sub>41.2</sub>Ti<sub>13.8</sub>Cu<sub>12.5</sub>Ni<sub>10</sub>Be<sub>22.5</sub> Bulk Metallic Glass.

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