Understanding PITX2-Dependent Atrial Fibrillation Mechanisms through Computational Models.

ABSTRACT: Atrial fibrillation (AF) is a common arrhythmia. Better prevention and treatment of AF are needed to reduce AF-associated morbidity and mortality. Several major mechanisms cause AF in patients, including genetic predispositions to AF development. Genome-wide association studies have identified a number of genetic variants in association with AF populations, with the strongest hits clustering on chromosome 4q25, close to the gene for the homeobox transcription PITX2. Because of the inherent complexity of the human heart, experimental and basic research is insufficient for understanding the functional impacts of PITX2 variants on AF. Linking PITX2 properties to ion channels, cells, tissues, atriums and the whole heart, computational models provide a supplementary tool for achieving a quantit

SUBMITTER: Bai J 

PROVIDER: S-EPMC8307824 | biostudies-literature | 2021 Jul

REPOSITORIES: biostudies-literature