Multiomics Profiling Reveals Signatures of Dysmetabolism in Urban Populations in Central India.

ABSTRACT:

Background

Non-communicable diseases (NCDs) have become a major cause of morbidity and mortality in India. Perturbation of host-microbiome interactions may be a key mechanism by which lifestyle-related risk factors such as tobacco use, alcohol consumption, and physical inactivity may influence metabolic health. There is an urgent need to identify relevant dysmetabolic traits for predicting risk of metabolic disorders, such as diabetes, among susceptible Asian Indians where NCDs are a growing epidemic.

Methods

Here, we report the first in-depth phenotypic study in which we prospectively enrolled 218 adults from urban and rural areas of Central India and used multiomic profiling to identify relationships between microbial taxa and circulating biomarkers of cardiometabolic risk

SUBMITTER: Monaghan TM 

PROVIDER: S-EPMC8307859 | biostudies-literature | 2021 Jul

REPOSITORIES: biostudies-literature