Assessment of Evolutionary Relationships for Prioritization of Myxobacteria for Natural Product Discovery.

ABSTRACT: Discoveries of novel myxobacteria have started to unveil the potentially vast phylogenetic diversity within the family Myxococcaceae and have brought about an updated approach to myxobacterial classification. While traditional approaches focused on morphology, 16S gene sequences, and biochemistry, modern methods including comparative genomics have provided a more thorough assessment of myxobacterial taxonomy. Herein, we utilize long-read genome sequencing for two myxobacteria previously classified as Archangium primigenium and Chondrococcus macrosporus, as well as four environmental myxobacteria newly isolated for this study. Average nucleotide identity and digital DNA-DNA hybridization scores from comparative genomics suggest previously classified as A. primigenium to

SUBMITTER: Ahearne A 

PROVIDER: S-EPMC8307915 | biostudies-literature | 2021 Jun

REPOSITORIES: biostudies-literature