SARS-CoV-2 acquisition and immune pathogenesis among school-aged learners in four diverse schools.

ABSTRACT:

Background

Understanding SARS-CoV-2 infection in children is necessary to reopen schools safely.

Methods

We measured SARS-CoV-2 infection in 320 learners [10.5 ± 2.1 (sd); 7-17 y.o.] at four diverse schools with either remote or on-site learning. Schools A and B served low-income Hispanic learners; school C served many special-needs learners, and all provided predominantly remote instruction. School D served middle- and upper-income learners, with predominantly on-site instruction. Testing occurred in the fall (2020), and 6-8 weeks later during the fall-winter surge (notable for a tenfold increase in COVID-19 cases). Immune responses and mitigation fidelity were also measured.

Results

We found SARS-CoV-2 infections in 17 learners only during the surge. School A (97% r

SUBMITTER: Cooper DM 

PROVIDER: S-EPMC8308070 | biostudies-literature | 2021 Nov

REPOSITORIES: biostudies-literature