Management of arterial partial pressure of carbon dioxide in the first week after traumatic brain injury: results from the CENTER-TBI study.

ABSTRACT:

Purpose

To describe the management of arterial partial pressure of carbon dioxide (PaCO₂) in severe traumatic brain-injured (TBI) patients, and the optimal target of PaCO₂ in patients with high intracranial pressure (ICP).

Methods

Secondary analysis of CENTER-TBI, a multicentre, prospective, observational, cohort study. The primary aim was to describe current practice in PaCO₂ management during the first week of intensive care unit (ICU) after TBI, focusing on the lowest PaCO₂ values. We also assessed PaCO₂ management in patients with and without ICP monitoring (ICP_m), and with and without intracranial hypertension. We evaluated the effect of profound hyperventilation (defined as PaCO₂ < 30 mmHg) on

SUBMITTER: Citerio G 

PROVIDER: S-EPMC8308080 | biostudies-literature | 2021 Sep

REPOSITORIES: biostudies-literature