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Changes in HMO Concentrations throughout Lactation: Influencing Factors, Health Effects and Opportunities.


ABSTRACT: Human milk oligosaccharides (HMOs) are important functional biomolecules in human breast milk. Understanding the factors influencing differences in HMO composition and changes in their concentration over lactation can help to design feeding strategies that are well-adapted to infant's needs. This review summarises the total and individual concentration of HMOs from data published from 1999 to 2019. Studies show that the HMO concentrations are highest in colostrum (average 9-22 g/L), followed by slightly lower concentrations in transitional milk (average 8-19 g/L), with a gradual decline in mature milk as lactation progresses, from 6-15 g/L in breast milk collected within one month of birth, to 4-6 g/L after 6 months. Significant differences in HMO composition have been described between countries. Different HMOs were shown to be predominant over the course of lactation, e.g., 3-fucosyllactose increased over lactation, whereas 2'-fucosyllactose decreased. Recent clinical studies on infant formula supplemented with 2'-fucosyllactose in combination with other oligosaccharides showed its limited beneficial effect on infant health.

SUBMITTER: Thum C 

PROVIDER: S-EPMC8308359 | biostudies-literature | 2021 Jun

REPOSITORIES: biostudies-literature

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Changes in HMO Concentrations throughout Lactation: Influencing Factors, Health Effects and Opportunities.

Thum Caroline C   Wall Clare Rosemary CR   Weiss Gisela Adrienne GA   Wang Wendan W   Szeto Ignatius Man-Yau IM-Y   Day Li L  

Nutrients 20210630 7


Human milk oligosaccharides (HMOs) are important functional biomolecules in human breast milk. Understanding the factors influencing differences in HMO composition and changes in their concentration over lactation can help to design feeding strategies that are well-adapted to infant's needs. This review summarises the total and individual concentration of HMOs from data published from 1999 to 2019. Studies show that the HMO concentrations are highest in colostrum (average 9-22 g/L), followed by  ...[more]

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