Association of Plasma Phospholipids with Age-Related Cognitive Impairment: Results from a Cross-Sectional Study.

ABSTRACT: Decreased concentration of phospholipids were observed in brain tissue from individuals with dementia compared with controls, indicating phospholipids might be a key variable in development of age-related cognitive impairment. The reflection of these phospholipid changes in blood might provide both reference for diagnosis/monitoring and potential targets for intervention through peripheral circulation. Using a full-scale targeted phospholipidomic approach, 229 molecular species of plasma phospholipid were identified and quantified among 626 senile residents; the association of plasma phospholipids with MoCA score was also comprehensively discussed. Significant association was confirmed between phospholipid matrix and MoCA score by a distance-based linear model. Additionally, the network an

SUBMITTER: Liu TT 

PROVIDER: S-EPMC8308406 | biostudies-literature | 2021 Jun

REPOSITORIES: biostudies-literature