Rapid Generation of Coronaviral Immunity Using Recombinant Peptide Modified Nanodiamonds.

ABSTRACT: Vaccination remains one of the most effective tools to prevent infectious diseases. To ensure that the best possible antigenic components are chosen to stimulate a cognitive immune response, boosting antigen presentation using adjuvants is common practice. Nanodiamond-based adjuvants are proposed here as a rapid and versatile platform for antigen conjugation, utilizing peptides common to different pathogenic strains and making this strategy a good candidate for a "ready-to-use" vaccine. Initiation of an inflammatory reaction with a resulting immune response is based on the ability of living organisms to entrap nanostructures such as nanodiamonds with neutrophil extracellular traps (NETs) formation. In this work, coronavirus peptide homological for MERS-CoV, fusion inhibitor, was conjugated

SUBMITTER: Bilyy R 

PROVIDER: S-EPMC8308543 | biostudies-literature | 2021 Jul

REPOSITORIES: biostudies-literature