Bioactive Compounds from Euphorbia usambarica Pax. with HIV-1 Latency Reversal Activity.

ABSTRACT: Euphorbia usambarica is a traditional medicine used for gynecologic, endocrine, and urogenital illnesses in East Africa; however, its constituents and bioactivities have not been investigated. A variety of compounds isolated from Euphorbia species have been shown to have activity against latent HIV-1, the major source of HIV-1 persistence despite antiretroviral therapy. We performed bioactivity-guided isolation to identify 15 new diterpenoids (1-9, 14-17, 19, and 20) along with 16 known compounds from E. usambarica with HIV-1 latency reversal activity. Euphordraculoate C (1) exhibits a rare 6/6/3-fused ring system with a 2-methyl-2-cyclopentenone moiety. Usambariphanes A (2) and B (3) display an unusual lac

SUBMITTER: Tsai YC 

PROVIDER: S-EPMC8308672 | biostudies-literature | 2021 Jul

REPOSITORIES: biostudies-literature